Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear
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چکیده
منابع مشابه
Patterning the artery wall by lateral induction of Notch signaling.
Blood vessels exhibit a common structure composed of layers of cells encircling a central lumen. Arteries generally have more layers than veins have, and different arteries in the same individual can have different numbers of layers. Because all blood vessels are built around a monolayer of endothelial cells, the variation in wall structure is due to variable numbers of smooth musclecontaining ...
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متن کاملDev108100 1..12
During inner ear development, Notch exhibits twomodes of operation: lateral induction, which is associated with prosensory specification, and lateral inhibition, which is involved in hair cell determination. These mechanisms depend respectively on two different ligands, jagged 1 (Jag1) and delta 1 (Dl1), that rely on a common signaling cascade initiated after Notch activation. In the chicken ot...
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ژورنال
عنوان ژورنال: Development
سال: 2014
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.108100